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KMID : 1007420060040020062
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Mood and Emotion
2006 Volume.4 No. 2 p.62 ~ p.69
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A Differential Pattern of Neural Response toward Happy versus Disgust Facial Expressions in Major Depressive Disorder : A fMRI Study
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Choi Kang
Lee Byeong-Taek
Seok Jeong-Ho
Jon Duk-In
Hong Hyun-Ju
Lee Byung-Chul
Han Chang-Hwan
Choi Ihn-Geun
Chae Jeong-Ho
Ham Byung-Joo
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Abstract
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Objectives：Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing. The purpose of this study was to investigate the specific brain regions associated with reactivity to negative and positive affective stimuli in patients with major depressive disorder (MDD).
Methods：Using functional magnetic resonance imaging (fMRI), neural responses to happy and disgust facial expressions were measured in 12 healthy control subjects and 12 patients with MDD.
Results：Compared to control subjects, MDD patients showed significant higher activation of right rostral anterior cingulate cortex (ACC) to happy and disgust facial expression. MDD patients also demonstrated significant activations of both fusiform face areas in fusiform gyrus to disgust facial expression compared to control subjects.
Conclusion：Our findings that activations to the negative facial stimuli increase in the right rostral ACC preferentially might be involved in the processing of emotional stimuli in depressed individuals.
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KEYWORD
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Depression, fMRI, Happy:Disgust, Facial stimuli
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